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New Building Blocks for October 2018 2018/10/11 15:22:18

leyan logo新品推薦 - 2018 年 10 月
有機合成砌塊、合成試劑、特色醫藥中間體
β-Lactams represent a privileged scaffold in organic synthesis in addition to their important role as the core motif in β-lactam antibiotics such as penicillins, cephalosporins, monobactams, and carbapanems.[1]
More recently molecules containing a β-lactam subunit have demonstrated additional therapeutic effects by functioning as antifungal[2], anticancer[3], and antiviral agents[4].
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[1]  Thomas C. Malig.; Diana Yu.; Jason E. Hein. J. Am. Chem. Soc. 2018, 140, 9167?9173.
[2]  Dhar N, et al. Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic. Antimicrob Agents Chemother. 2015 Feb;59(2):1308-19.
[3]  Banik, Bimal K.; Banik, Indrani; Becker, Frederick F. European Journal of Medicinal Chemistry (2010), 45(2), 846-848.
[4]  Gerona-Navarro, G.; Pe?rez De Vega, M. J.; García-Lo?pez, M. T.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J.; Gonza?lez-Mun?iz, R. J. Med. Chem. 2005, 48, 2612?2621.
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